Flexible PPG sensor patch

Principal Investigator:Paul C.-P. Chao


The project aims to the development of a flexible PPG sensor patch for measuring pulsations of blood vessels estimating ambulatory blood pressure monitoring (ABPM). After one year of project execution, a new company will be founded. The flexible PPG sensor patch to develop in this one year employs novel materials and processes to integrate optical sensor in a single flexible patch, to be attached on human skin for measurement. The measured quality PPG signals are analyzed to estimate blood pressure (BP), heart rate (HR), blood oxygen and atrial fibrillation (A-Fib). The PPG sensing patches with arrayed optical sensor effectively overcome the inevitable problem of wearable devic-es — sensing quality is seriously subjected to the motion artifacts of the subject's wrist during motion and mi-positioning of the patch to the blood vessel. Therefore, the developed patch can measure the forementioned target bio-signs with much higher accuracy than commercial health bracelets. In this way, with subject’s physiological condition apprehended accurately, timely hospitalization can be advised.

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Team Introduction

The Sensor IC Design laboratory (SIL) research focuses on the estimation of highly accurate Blood flow and blood pressure based on PPG sensor and advance AI-algorithm. Also, the recent success of SIL lab, NCTU group on detecting pulsation of blood vessel via a portable PPG mention in the journal papers.The obtained results indicate that detection of pulse intervals based on PPG is a sensitive and accurate screening tool for the detection of BP/BFV and has a high level of agreement with medical standards.

Goals and Plan

In the early days of its establishment, the company will focus on the development of various flexible PPG sensing patches, as well as the productivity and production quality of the sensing patches. In the initial stage of operation (1st years), the sales of sensory patches offered to a brand company will be used as a source of income. In the initial stage, a large number of PPG physiological data will be collected. Big data analysis and deep learning will be employed to develop the algo-rithms for detecting BP, HR and blood oxygen. In the mid-term (2nd -3rd years),the company will finish clinical trials for FDA approval on the BP sensing patch, and have the BP pacth on sale at 2021Q4. In the long-term phase (4th~6th years), the company will cooperate with the Health Moni-toring Medical System brad company to develop and sell a patch-type arrhythmia/ atrial fibrillation recorder. It is estimated that the company will post a surplus in Q4 of the third years (2022Q2)

Entry Barrier

Some ABPM system consist PPG and ECG sensor. However, ECG patch has drawbacks of (1) skin preparation / varied interface impedance; (2) some of the arrhythmia’s types cannot be ducted by ECG by the paper published in American Heart Association. The flexible PPG patch only needs the PPG sensor. The core technologies of flexible PPG patch are:

1. For best sensing results and high-quality PPG, the light should be in the infrared range in order to sufficiently penetrate the tissue covering the wrist artery.

2. Used to minimize the issue of Mis-positioning and provide error free high-quality PPG signals.

3. Fully flexible and Highly Adaptive and highly efficient PPG readout circuit design includes TIA, Bandpass filter, PGA, ADC, Power management, Transceiver, adaptive intensity and gain controller.

Market Scope

 The global ambulatory blood pressure monitoring devices market was valued at US$ 80.5 mil-lion in 2017, and expected to reach US$ 128.0 million by 2023 at a CAGR of 6.3% during the fore-cast period from 2017 to 2023. For the smart medical device market, the blood pressure monitors, heart rate monitors and the pulse oximeters share more than 60% smart medical device market. In the milestone, the sharing of patch PPG sensor are 0.1% (150 pcs/month) in 2021 and 1.52% (800 pcs/month) in 2023 of ABPM market.